Shulman, LM; Mendelson, E; Anis, E; Bassal, R; Gdalevich, M; Hindiyeh, M; Kaliner, E; Kopel, E; Manor, Y; Moran-Gilad, J; Ram, Diana; Sofer, D; Somekh, E; Tasher, D; Weil, M; Gamzu, R; Grotto, I.
Título
Laboratory challenges in response to silent introduction and sustained transmission of wild poliovirus type 1 in Israel during 2013.
Resumen
Wild poliovirus type 1 (WPV1) introduction into southern Israel in early 2013 was detected by routine environmental surveillance. The virus was identified genetically as related to the South Asian (SOAS) R3A lineage endemic to Pakistan in 2012. Intensified, high-throughput environmental surveillance using advanced molecular methods played a critical role in documenting and locating sustained transmission throughout 2013 and early 2014 in the absence of any acute flaccid paralysis. It guided the public health responses, including stool-based surveillance and serosurveys, to determine the point prevalence in silent excretors and measured the effect of vaccination campaigns with inactivated polio vaccine and bivalent oral polio vaccine on stopping transmission.(AU)
Descriptores DECS
TECNICAS DE LABORATORIO CLINICO; MONITOREO DEL AMBIENTE; HECES^sVirología; ISRAEL^sEpidemiología; TECNICAS DE DIAGNOSTICO MOLECULAR^sMétodos; POLIOMIELITIS^sEpidemiología; POLIOMIELITIS^sTransmisión; POLIOMIELITIS^sPrevención y control; POLIOVIRUS^sAislamiento y purificación; VACUNA ANTIPOLIO ORAL^sAdministración y dosificación; AGUAS DEL ALCANTARILLADO; ESPARCIMIENTO DEL VIRUS
